Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

Gregory W. Albers et al. · PI Gregory Albers, MD

Primary endpoint

The Distribution of Scores on the Modified Rankin Scale (mRS) at Day 90

Population

Stroke, Acute, Cerebral Infarction; n=182

doi:10.1056/NEJMoa1713973

Historical

Current

Future

3 noemes

Historical

1 noeme

Published findings from this trial. Vote whether the expert body still believes each noeme stands given current evidence.

The DEFUSE-3 trial's stated primary conclusion — Imaging-selected patients benefit from thrombectomy 6–16h after last-known-well. — replicates in independent cohorts.

neurointerventional

Current

1 noeme

Noemes tracking active replication, subgroup analysis, or long-term follow-up. Vote on the likelihood the original effect holds.

Recent follow-up analyses of DEFUSE-3 are confirming the original effect size in real-world data.

neurointerventional

Future

1 noeme

Open forecast horizons tied to this trial. Vote your probability that each resolves TRUE by the declared horizon.

By 2028, imaging-based (CTP/MR) selection for late-window thrombectomy will be reimbursed by CMS without pre-authorization.

neurointerventional

71%

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