A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

Olvert A. Berkhemer et al.

doi:10.1056/NEJMoa1411587

Historical

Current

Future

3 noemes

Historical

1 noeme

Published findings from this trial. Vote whether the expert body still believes each noeme stands given current evidence.

The MR CLEAN trial's stated primary conclusion — Endovascular thrombectomy within 6h improves functional outcome in proximal anterior circulation stroke. — replicates in independent cohorts.

neurointerventional

Current

1 noeme

Noemes tracking active replication, subgroup analysis, or long-term follow-up. Vote on the likelihood the original effect holds.

Recent follow-up analyses of MR CLEAN are confirming the original effect size in real-world data.

neurointerventional

Future

1 noeme

Open forecast horizons tied to this trial. Vote your probability that each resolves TRUE by the declared horizon.

By 2028, the MR CLEAN effect size (~13% absolute mRS 0–2 improvement) will be confirmed within ±3 points in pooled real-world US registries.

neurointerventional

71%

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