Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

Jeffrey L. Saver et al. · PI Jeffrey Saver, MD

Primary endpoint

90-day Global Disability Assessed Via the Blinded Evaluation of Modified Rankin Score (mRS).

Population

Acute Ischemic Stroke; n=196

doi:10.1056/NEJMoa1415061

Historical

Current

Future

3 noemes

Historical

1 noeme

Published findings from this trial. Vote whether the expert body still believes each noeme stands given current evidence.

The SWIFT PRIME trial's stated primary conclusion — Stent-retriever thrombectomy plus tPA is superior to tPA alone for proximal anterior-circulation stroke. — replicates in independent cohorts.

neurointerventional

Current

1 noeme

Noemes tracking active replication, subgroup analysis, or long-term follow-up. Vote on the likelihood the original effect holds.

Recent follow-up analyses of SWIFT PRIME are confirming the original effect size in real-world data.

neurointerventional

Future

1 noeme

Open forecast horizons tied to this trial. Vote your probability that each resolves TRUE by the declared horizon.

By 2028, stent retrievers will remain first-line device class, with next-gen aspiration-plus-stent hybrids not yet unseating them in RCTs.

neurointerventional

71%

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