Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

Bruce C.V. Campbell et al.

Primary endpoint

Reperfusion at 24 hours (CT or MR perfusion imaging)

Population

Ischemic Stroke; n=70

doi:10.1056/NEJMoa1414792

Historical

Current

Future

3 noemes

Historical

1 noeme

Published findings from this trial. Vote whether the expert body still believes each noeme stands given current evidence.

The EXTEND-IA trial's stated primary conclusion — CT-perfusion-selected thrombectomy produces early neurological improvement vs. tPA alone. — replicates in independent cohorts.

neurointerventional

Current

1 noeme

Noemes tracking active replication, subgroup analysis, or long-term follow-up. Vote on the likelihood the original effect holds.

Recent follow-up analyses of EXTEND-IA are confirming the original effect size in real-world data.

neurointerventional

Future

1 noeme

Open forecast horizons tied to this trial. Vote your probability that each resolves TRUE by the declared horizon.

By 2028, CT-perfusion will be standard at the majority of thrombectomy-capable centers, matching the EXTEND-IA selection criteria.

neurointerventional

71%

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