Initial Invasive or Conservative Strategy for Stable Coronary Disease

David J. Maron et al. · PI David J Maron, MD

Primary endpoint

Primary Composite Outcome: Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest

Population

Cardiovascular Diseases, Coronary Disease, Coronary Artery Disease; n=5179

doi:10.1056/NEJMoa1915922

Historical

Current

Future

3 noemes

Historical

1 noeme

Published findings from this trial. Vote whether the expert body still believes each noeme stands given current evidence.

The ISCHEMIA trial's stated primary conclusion — In stable CAD with moderate-to-severe ischemia, an initial invasive strategy does not reduce cardiovascular events vs. optimal medical therapy. — replicates in independent cohorts.

cardiology

Current

1 noeme

Noemes tracking active replication, subgroup analysis, or long-term follow-up. Vote on the likelihood the original effect holds.

Recent follow-up analyses of ISCHEMIA are confirming the original effect size in real-world data.

cardiology

Future

1 noeme

Open forecast horizons tied to this trial. Vote your probability that each resolves TRUE by the declared horizon.

By 2028, elective PCI rates for stable CAD will have declined by ≥15% in the US post-ISCHEMIA, stabilizing at a new lower baseline.

cardiology

71%