Published finding — does the expert body still believe it?
The CLARITY-AD (lecanemab) trial's stated primary conclusion — Lecanemab slows cognitive decline in early Alzheimer disease with amyloid confirmation, with a non-trivial ARIA safety signal. — replicates in independent cohorts.
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Evidence stream
2 events · 1 snapshot
posterior drift
71% → 71% (0pp · 1 point)
Registry data
Apr 18, 2026
Peer-reviewed paper
Apr 18, 2026
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Source publication
Lecanemab in Early Alzheimer’s Disease
Christopher H. van Dyck et al. · New England Journal of Medicine · 2023
· openalex W4310461604
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The EMERGE (aducanumab) trial's stated primary conclusion — Aducanumab’s pivotal phase 3 showed mixed evidence for cognitive slowing in early Alzheimer disease. — replicates in independent cohorts.
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Recent follow-up analyses of CLARITY-AD (lecanemab) are confirming the original effect size in real-world data.
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Recent follow-up analyses of EMERGE (aducanumab) are confirming the original effect size in real-world data.
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By 2028, anti-amyloid antibodies will have a net positive impact on real-world CDR-SB trajectories, but uptake will remain <25% of eligible early AD patients due to ARIA monitoring burden.
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By 2028, aducanumab will have been withdrawn or deprioritized in favor of later anti-amyloid agents with cleaner efficacy signals.
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Recent follow-up analyses of EMILIA are confirming the original effect size in real-world data.