Active replication — ongoing trial, registry, or meta-analysis.
Recent follow-up analyses of CLARITY-AD (lecanemab) are confirming the original effect size in real-world data.
TL;DR · AI-generated
Lecanemab reduced markers of amyloid in early Alzheimer's disease and resulted in moderately less decline on measures of cognition and function than placebo at 18 months but was associated with adverse events.
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Evidence stream
2 events · 1 snapshot
posterior drift
71% → 71% (0pp · 1 point)
Registry data
Apr 18, 2026
Peer-reviewed paper
Apr 18, 2026
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Source publication
Lecanemab in Early Alzheimer’s Disease
Christopher H. van Dyck et al. · New England Journal of Medicine · 2023
· openalex W4310461604 · s2 d18c2765
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The CLARITY-AD (lecanemab) trial's stated primary conclusion — Lecanemab slows cognitive decline in early Alzheimer disease with amyloid confirmation, with a non-trivial ARIA safety signal. — replicates in independent cohorts.
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