Active replication — ongoing trial, registry, or meta-analysis.
Recent follow-up analyses of ADVANCE (atogepant) are confirming the original effect size in real-world data.
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Evidence stream
1 event · 0 snapshots
Registry data
Apr 18, 2026
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Source publication
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine (ADVANCE)
Semantically related
Nearest claims in the expert-corpus vector space. Ordered by cosine distance — lower is closer.
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The ADVANCE (atogepant) trial's stated primary conclusion — Atogepant, an oral CGRP receptor antagonist, reduces monthly migraine days in episodic migraine preventive therapy. — replicates in independent cohorts.
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Recent follow-up analyses of DAWN are confirming the original effect size in real-world data.
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Recent follow-up analyses of MEMBRANE are confirming the original effect size in real-world data.
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Recent follow-up analyses of ESCAPE are confirming the original effect size in real-world data.
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Recent follow-up analyses of EXTEND-IA are confirming the original effect size in real-world data.
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Recent follow-up analyses of EMERGE (aducanumab) are confirming the original effect size in real-world data.