Published finding — does the expert body still believe it?
The ADVANCE (atogepant) trial's stated primary conclusion — Atogepant, an oral CGRP receptor antagonist, reduces monthly migraine days in episodic migraine preventive therapy. — replicates in independent cohorts.
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Evidence stream
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Registry data
Apr 18, 2026
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Source publication
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine (ADVANCE)
Semantically related
Nearest claims in the expert-corpus vector space. Ordered by cosine distance — lower is closer.
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Recent follow-up analyses of ADVANCE (atogepant) are confirming the original effect size in real-world data.
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By 2028, oral CGRP antagonists will be first-line preventive therapy for episodic migraine, surpassing beta-blockers in new prescriptions.
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The MEMBRANE trial's stated primary conclusion — Middle meningeal artery embolization reduces recurrence of chronic subdural hematoma. — replicates in independent cohorts.
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Recent follow-up analyses of MEMBRANE are confirming the original effect size in real-world data.
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Recent follow-up analyses of ESCAPE are confirming the original effect size in real-world data.
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The EMERGE (aducanumab) trial's stated primary conclusion — Aducanumab’s pivotal phase 3 showed mixed evidence for cognitive slowing in early Alzheimer disease. — replicates in independent cohorts.