Forecast horizon — calibration-scored at resolution.
By 2028, late-window thrombectomy (6–24h) will be explicitly endorsed by AHA/ASA guidelines as standard-of-care in qualifying LVO patients across at least 80% of US comprehensive stroke centers.
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Evidence stream
2 events · 1 snapshot
posterior drift
71% → 71% (0pp · 1 point)
Registry data
Apr 18, 2026
Peer-reviewed paper
Apr 18, 2026
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Source publication
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
Raul G. Nogueira et al. · New England Journal of Medicine · 2018
· openalex W2767776410 · s2 e3b1d93d
Semantically related
Nearest claims in the expert-corpus vector space. Ordered by cosine distance — lower is closer.
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By 2028, median door-to-puncture time at thrombectomy centers will meet or beat the ESCAPE benchmark of ≤60 minutes.
0.1269
By 2028, CT-perfusion will be standard at the majority of thrombectomy-capable centers, matching the EXTEND-IA selection criteria.
0.1276
By 2028, imaging-based (CTP/MR) selection for late-window thrombectomy will be reimbursed by CMS without pre-authorization.
0.1661
The DAWN trial's stated primary conclusion — Mechanical thrombectomy benefits selected large-vessel-occlusion stroke patients in the 6–24h window. — replicates in independent cohorts.
0.1708
The DEFUSE-3 trial's stated primary conclusion — Imaging-selected patients benefit from thrombectomy 6–16h after last-known-well. — replicates in independent cohorts.
0.1722
The benefit of late-window thrombectomy identified in DEFUSE 3 will generalize to stroke patients with posterior circulation (basilar artery) occlusion selected by perfusion imaging in the 6-16 hour window.