All noemes
Trial · NCT03036488

Noeme · rnca262f

Historical
oncology

Published finding — does the expert body still believe it?

The KEYNOTE-522 trial's stated primary conclusion — Neoadjuvant pembrolizumab + chemotherapy increases pathologic complete response rate in triple-negative breast cancer. — replicates in independent cohorts.

Your position — does this noeme still stand given current evidence?

0% (impossible)

50%

100% (certain)

25
50
75

Proper-scoring-rule preview

If TRUE: Brier 0.250 · log 0.69 · +8 rep
If FALSE: Brier 0.250 · log 0.69 · -1 rep
Kelly 25.0% ≈ 250 rep

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Evidence stream

2 events · 1 snapshot

posterior drift

71% → 71% (0pp · 1 point)

posterior drift: 71% → 71%
neutral

Registry data

NCT03036488

Apr 18, 2026

supports

Peer-reviewed paper

+21pp

Expert reactions · 0

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Source publication

Pembrolizumab for Early Triple-Negative Breast Cancer

Peter Schmid et al. · New England Journal of Medicine · 2020

3.0k citations
FWCI 136.5 · Landmark
OA · bronze
21 authors · 81% ORCID

· openalex W3006930853