All noemes
Trial · NCT02140554

Noeme · 8zlxazq6

Active replication — ongoing trial, registry, or meta-analysis.

Recent follow-up analyses of HGB-206 (lovo-cel) are confirming the original effect size in real-world data.

Your position — does this noeme still stand given current evidence?

0% (impossible)

50%

100% (certain)

25
50
75

Proper-scoring-rule preview

If TRUE: Brier 0.250 · log 0.69 · +8 rep
If FALSE: Brier 0.250 · log 0.69 · -1 rep
Kelly 25.0% ≈ 250 rep

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Evidence stream

1 event · 0 snapshots

neutral

Registry data

NCT02140554

Apr 18, 2026

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Source publication

A Phase 1/2 Study Evaluating Gene Therapy by Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo With the LentiGlobin BB305 Lentiviral Vector in Subjects With Severe Sickle Cell Disease