Active replication — ongoing trial, registry, or meta-analysis.
Recent follow-up analyses of PARADIGM-HF are confirming the original effect size in real-world data.
TL;DR · AI-generated
LCZ696 was superior to enalapril in reducing the risks of death and of hospitalization for heart failure and decreased the symptoms and physical limitations of heart failure.
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Evidence stream
2 events · 1 snapshot
posterior drift
71% → 71% (0pp · 1 point)
Registry data
Apr 18, 2026
Peer-reviewed paper
Apr 18, 2026
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Source publication
Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
John J.V. McMurray et al. · New England Journal of Medicine · 2014
· openalex W2113698123 · s2 9ca73cac
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